Binding was CXCR2-dependent, as CXCL5-Fc bound to CXCR2-positive K562 human chronic myelogenous leukemia (CML) cells but not to isogenic CXCR2-negative K562 cells (Figure S4). Here, CXCL5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.