They produce a diverse population of exosomes that have a direct effect on all immune system cells through a wide variety of mechanisms that include polarization of innate cells to tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs), inhibiting some cells such as DC or lymphocytes T, upregulating Treg, suppressing NK cells by downregulation of some receptors like CD107a or NKG2D, and inducing myeloid-derived suppressor cells (MDSCs) [5,26,93,95]. This evidence concerns the gene KLRK1 and neoplasm.