Nbs have also the ability to be used to introduce them as chimeric antigen receptor constructs in T cells or NK creating CAR-T or CAR-NK and blocking some surface receptors expressed by tumor cells that are crucial to tumor signaling and survival like EGFR, HER2, VEGF receptor (VEGFR), c-Met and CXCR7 [19,21,71,72,73,74,88]. The gene discussed is ACKR3; the disease is neoplasm.