Suppression of human umbilical vein endothelial cells (HUVECs’) migration, capillary tube formation, and cell proliferation and downregulation of MMP2, MMP7, MMP9, and MMP12 and reduction of the volume, angiogenesis, and metastasis of tumour, in addition to increased p38 and JNK activity and decreased ERK activity. This evidence concerns the gene MAPK8 and neoplasm.