CASP3 and cancer: Prevention of tumour growth via activating caspase-3 and -9, raising the Bax/Bcl-2 ratio, which caused apoptosis, and downregulation of the HIF-1α, VEGF, and VEGFR2 signalling pathway. In addition, decreasing the expression of cyclin B1 and D1 while increasing the expression of Claudin-1 and ZO-1 decreased the growth of cancer cells.