When C6 glioma cells were implanted in Wistar rats, HSP prevented tumour growth by activating caspase-3 and -9, raising the Bax/Bcl-2 ratio, which caused apoptosis, and downregulating the HIF-1α, VEGF, and VEGFR2 signalling pathways. The gene discussed is HIF1A; the disease is neoplasm.