Reduction of the viability of breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-453, in addition to induction of apoptosis in MDA-MB-453 cells via the intrinsic pathway (caspase cascade activation PARP cleavage and cytochrome C release) and suppression of tumour growth and angiogenesis via inhibiting MMP-9, MMP-2, and uPA expression in BALB/c naked mice with MDA-MB-453 cell xenografts. This evidence concerns the gene MMP2 and neoplasm.