ERBB2 and breast carcinoma: At a concentration of 95 μM, HSP reduced HER2, MMP-9, and Rac1 expression, lamellipodia formation, and arrested the cell cycle at the G2/M phase, thereby lowering cell viability, invasion and migration, and promoting apoptosis, according to research conducted on HER2 overexpressed breast cancer cells (MCF-7/HER2) and MCF-7/EV cells [145].