For instance, as shown in Figure 5G, the chromatin region of TCNE-EBF1 (chr5:158,257,670–158,257,898) and that of the EBF1 gene promoter showed a strong interaction, and it had been demonstrated that EBF1 is highly expressed in triple-negative breast cancer cells, and the knockdown of EBF1 can block tumor growth and invasion [51]. Here, EBF1 is linked to triple-negative breast carcinoma.