FTO and Parkinson disease: In the study involving PC12 cells induced by the neurotoxin 6-hydroxydopamine (6-OHDA) and the striatum of rat models of PD, Chen et al. found that overexpression of FTO in dopaminergic cells or downregulating m6A levels using the m6A inhibitor cycloleucine led to an up-regulation of NMDAR1 expression [22].