The convergence of these environmental stressors with genetic vulnerabilities—such as variations in transcription factor sp4 (SP4), histone–lysine N-methyltransferase SETD1A, triple functional domain protein (TRIO), zinc finger protein 804A (ZNF804A), contactin-4 (CNTN4), leucine-rich repeat-containing protein 4B (LRRC4B), and netrin receptor DCC (DCC) [74,75,76,77]—is thought to contribute to the occurrence of schizophrenia symptoms [78]. Here, SP4 is linked to schizophrenia.