AQP4 and schizophrenia: At the molecular level, schizophrenia has been associated with the decreased expression of glutamate transporter-1 (GLT-1)—also known as excitatory amino acid transporter 2 (EAAT2) [45]—as well as reductions in GFAP [46], aldehyde dehydrogenase 1 (ALDH1), Ca2+-binding protein (S100A4), aquaporin 4 (AQP4), glutaminase, and thrombospondin (TSB1) expression [42,47,48,49].