Alpha-1 blockers are multifunctional drugs employed in diverse medical contexts, such as preventing postoperative urinary retention (POUR) [41], addressing benign prostatic hyperplasia (BPH) [42] and lower urinary tract symptoms (LUTS) in females [43], aiding ureteric stone expulsion [44], and treating premature ejaculation [45]. The gene discussed is PSMA6; the disease is premature ejaculation.