APOE and Ureteral obstruction: Despite limited research references, our team and others have shown that SFN-I induces downregulated CD36 expression and ectopic lipid accumulation in the arterial walls of apoE−/− mice and in the kidneys of unilateral ureteral obstruction mice, but does not affect CD36 expression in the hearts of HFD + STZ-treated mice [53,70,71].