Other AMD characteristics such as the development of drusen and RPE changes have been assessed in antioxidant and toxic response genes knockout mouse models for superoxide dismutase family (Sod-1 and 2), Nrf2, and aryl hydrocarbon receptor (Ahr, nuclear receptor that regulates cellular response to environmental signals, including UV and blue wavelength light) [51,52,53,54,55]. The gene discussed is AHR; the disease is age-related macular degeneration.