In terms of H2O2-mediated signaling cascades at the plasma membrane in cells activated by growth factors such as the epidermal growth factor (EGF), platelet-derived growth factor (PDGF), or insulin-like growth factor (IGF), further studies should elucidate the regulatory mechanism of the phosphoinositide 3-kinase (PI3K)-Akt/PKB-mTORC axis by H2O2 to understand the role of H2O2 in metabolic diseases and cancer progression. The gene discussed is AKT1; the disease is cancer.