AGT and Myocardial fibrosis: For example, Xie et al. found that U. rhynchophylla extract supplementation via the oral administration at 0.78, 1.56, and 3.12 g/kg body weight per day for twenty-eight days can effectively inhibit the TGF-β, RhoA, and Rho-associated coiled-coil protein kinase 1 (ROCK1) proteins, following to inhibit angiotensin II-induced myocardial fibrosis in mice [20].