Our data also demonstrated that treatment with exogenous H2O2 in differentiated NG108-15 cells markedly increased REST expression and decreased Cav2.2-α expression in vitro experiments (Figure 1), whereas Ad.CAT gene in vivo-transfected into AVG neurons attenuated REST protein expression (Figure 2) and increased Cav2.2-α expression in the AVG from T2DM rats [26]. Here, REST is linked to type 2 diabetes mellitus.