These findings are consistent with in vitro ER stress studies that demonstrated reduced expression of Grp78 and/or Chop following [MnTM-4-PyP]5+ treatment in primary rat cortical neurons exposed to H2O2 [57] and after [MnTM-4-PyP]5+ administration in lung adenocarcinoma cells (A549) [68]. This evidence concerns the gene HSPA5 and lung adenocarcinoma.