TP53 and neoplasm: RNA-seq analysis of spleen tissues from mandarin fish infected with SDDV identified key immune-related biological functions, particularly pathways involved in the cell cycle, P53-mediated tumor suppression, antigen processing/presentation, the complement/coagulation cascades, and cytokine–cytokine receptor interactions, and the IL-17, JAK-STAT, and PI3K-Akt signaling pathways (Figure 7A).