Compared with the control group, the mRNA expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) was significantly increased in the AngII (0.1 μmol/L) group (p < 0.01), suggesting that the cardiac hypertrophy model was successfully established (Figure 13A,B). This evidence concerns the gene NPPA and cardiac hypertrophy.