The AMP-activated protein kinase (AMPK)/Sirtuin 1 (SIRT1)/Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling axis, a master regulator of mitochondrial biogenesis and energy metabolism, has emerged as a promising therapeutic target for IBD [11]. The gene discussed is PPARGC1A; the disease is inflammatory bowel disease.