HMOX1 and fibrosarcoma: Under oxidative stress, Keap1 releases Nrf2, allowing it to translocate into the nucleus where it dimerizes with small musculoaponeurotic fibrosarcoma (sMaf) proteins and bind to the antioxidant response element (ARE), leading to the expression of its antioxidant target genes such as superoxide dismutase (SOD), glutathione-s-transferase (GST), catalase (CAT), glutathione peroxidase-1 (GPx-1), heme oxygenase-1 (HO-1), and NADPH quinone reductase-1 (NQO1) [64,65].