CASP1 and autoimmune polyendocrinopathy: Fibrosis factors (N-cadherin, α-SMA) and inflammatory factors (NLRP3, ASC, Caspase-1, and IL-1β) were significantly reduced in the mammary tissue of LPS+APS group, while the expression of the epithelial marker E-cadherin increased markedly (Figure 6A–D).