GPX4 and neoplasm: Additionally, exosome-mediated delivery of glutamic-oxaloacetic transaminase 1 (GOT1) has been shown to upregulate C-C motif chemokine receptor 2 (CCR2) and stimulate Nrf2–HO-1 signaling, promoting GPX4 expression and reducing ROS, MDA, and Fe2+, and ultimately enhancing tumor cell migration and invasion [78,79].