Their activation is orchestrated by a network of tumor-derived factors, including cytokines transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), Hepatocyte Growth Factor (HGF), chemokine C-C motif ligand 2 (CCL2), C-X-C motif chemokine ligand 12 (CXCL12), and inflammatory mediators such as Interleukin-1β (IL-1β) and Interleukin 6 (IL-6) [5,15,16,17,18,19]. The gene discussed is CCL2; the disease is neoplasm.