APLN and atherosclerosis: The 614 unique DEGs in the HB+15 vs. HB−20 comparison were enriched in 11 pathways, primarily including the apelin signaling pathway (oas04371), fluid shear stress and atherosclerosis (oas05418), the TNF signaling pathway (oas04668), osteoclast differentiation (oas04380), ABC transporters (oas02010), and taurine and hypotaurine metabolism (oas00430).