TLR4 and Sepsis: In a study examining the improvement of sepsis-induced lung injury by Shikonin through the modulation of miRNA-140-5p/TLR4-a in vitro and in vivo, it was discovered that miRNA-140-5p targets the TLR4 gene, leading to the suppression of TLR4 expression and the inhibition of downstream MyD88 and NF-κB protein expression [49].