With respect to VC, the group of Zare et al. broke new ground when evaluating peritumoral TB in 82 cases of VC for the first time, showing not only its impact on overall survival but also its aim at deciphering its associations with HPV status as well as p53 mutational status [9]—a finding especially true for the field of head and neck cancer not only for research groups such as Stögbauer et al. but also our own studies, which showed a clear association of higher budding formation with a negative HPV status [18,19]. This evidence concerns the gene TP53 and head and neck cancer.