Abnormalities in the KMT2D (lysine methyltransferase 2D) gene contribute to the development of various types of cancer, including medulloblastoma, melanoma, lymphomas, leukemia, and cancers of the lung, prostate, kidney, bladder, ovary, pancreas, esophagus, and stomach [62,63,64,65,66,67,68,69,70,71,72,73,74,75,76], disrupting genetic and epigenetic regulation and promoting tumor initiation, progression, and metastasis. Here, KMT2D is linked to leukemia.