TNF and rheumatoid arthritis: On the other hand, a systematic review with meta-analysis of 62 randomized controlled trials (RCTs) and 16 long-term extension (LTE) evaluated the safety of JAK inhibitors compared to placebo, TNFα inhibitors, and methotrexate in adults with various immune-mediated conditions, such as rheumatoid arthritis, psoriatic arthritis, psoriasis, and IBD [31].