This contrasts with BCC, which is associated with significantly increased systemic levels of immunosuppressive TGF-β1, as well as those of the soluble co-inhibitory immune checkpoints, cytotoxic T-lymphocyte antigen-4 (CTLA-4), lymphocyte activation gene 3 (LAG-3), PD-1, PD-L1, and T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) [103]. The gene discussed is TGFB1; the disease is skin basal cell carcinoma.