However, in the case of cSCC, the authors established the involvement of upregulated CCR5 ligands, as well as that of several other chemokines, including CXCL9, CXCL10, and CXCL11, in maintaining a state of immunosuppression during well-defined stages of cSCC progression [79]. The gene discussed is CCR5; the disease is skin squamous cell carcinoma.