PTGS2 and cancer: Stromal cells in the OC-TME, under the influence of pro-inflammatory mediators like prostaglandin E-2 (PGE2) and cyclooxygenase-2 (COX-2), also express and produce stromal-derived factor-1 (SDF1), which, upon binding to its receptor CXCR4 on cancer cells, induces angiogenesis and immune cells recruitment [96].