Loss of E-cadherin results in the weakening of cell-to-cell adhesion, and subsequent detachment of the epithelial cells from the underlying basement membrane leads to increased invasiveness of OC cells from tumor sites and is related to poor prognosis by upregulating expression of specific adhesion molecules (such as α5-integrin and CD44) that mediate cancer cell adhesions to mesothelial cells lining the abdominal cavity [157]. The gene discussed is CDH1; the disease is cancer.