Upon exposure to TNF (tumor necrosis factor) and PGE2 (prostaglandin E2) secreted by PDAC cells infiltrating monocytes differentiated to IL-1β+ TAMs and facilitated inflammatory reprogramming of cancer cells to potentiate the release of TNF, PGE2, and other factors for maintenance of an IL-1β+ TAM state. The gene discussed is TNF; the disease is cancer.