When analyzing tumor grade, we found that high-grade tumors (grade 3 endometrioid and non-endometrioid EC) exhibited significantly higher levels of 11OHA4 (p = 0.012), 11KA4 (p = 0.008), CA-125 (p < 0.001) and HE4 (p = 0.005) compared to low-grade tumors (grade 1–2 endometrioid EC). This evidence concerns the gene MUC16 and neoplasm.