Our data suggest a potential link between (a) mutation in PMS2 with the BCC-associated STR somatic mutations in LRP1B, PRKDC, ATM, and BRAF and (b) mutation in MLH1 and STR somatic mutation in APC (significant associations between MMR and STR mutations are highlighted in yellow in Table 1). This evidence concerns the gene PRKDC and skin basal cell carcinoma.