BCC patients with BCC-associated STR somatic mutations in BRAF or APC show more marked overexpression of the hedgehog signaling pathway (see Figure 9) and so are more likely to respond to hedgehog (Hh) inhibitors like Vesmodigib or Sonidegib, which are currently used [27,28,29,30,31]. Here, APC is linked to skin basal cell carcinoma.