It has been shown that SREBP1 activity is required for the palmitoylation of Ras in the progression and metastasis of Ras-dependent breast cancers, and that suppression of transcriptional activity of SREBP1 through the interaction of CLDN6 with MAGI2 and KLF5 reduces palmitic acid biosynthesis and palmitoylation of Ras [89]. The gene discussed is SREBF1; the disease is breast carcinoma.