MKI67 and neoplasm: In addition, according to the North American Neuroendocrine Tumor Society (NANETS) guidelines, observation could be a good choice for NF-PANNETs < 1 cm, but the management of NF-PANNETs 1–2 cm should be personalized based on various factors such as age, endoscopic ultrasonography-end-needle aspiration or endoscopic ultrasonography–biopsy findings (grade, Ki-67), comorbidities, anatomical location, tumor growth status, patient preferences, extent of procedure required for complete resection, and access to long-term follow-up [32].