For example, a systematic examination of the combination of MDV3100 (an AR antagonist) [99] and BKM120 (a PI3K inhibitor) [100], TKI258 (a pan-RTK inhibitor) [101], and RAD001 (an mTOR inhibitor) [102] on various PCa cell lines (LNCaP, VCaP, 22Rv1, PC-3, and DU-145) revealed significant findings. The gene discussed is PIK3CA; the disease is posterior cortical atrophy.