IGF2BP2 and neoplasm: In addition, IGF2BP2 was shown to promote cell proliferation and metabolic reprogramming to support rapid tumour growth through the activation of the PI3K/AKT signalling pathway as well as through the stimulation of the glycolytic activity in PDAC cells by stabilizing the mRNA of GLUT1/SLC2A1, thus enhancing its expression level and facilitating increased glucose uptake [154,159].