In contrast, due to the lack of association between proliferation profiles and HIF-1α/HIF-2α overexpression, this molecular variable showed no significant associations with tumor burden (χ2 = 1.102, p = 0.524), tumor recurrence (χ2 = 0.900, p = 0.524), or disease severity (χ2 = 0.900, p = 0.635). This evidence concerns the gene EPAS1 and neoplasm.