When comparing these values with non-hemangioblastoma cell lines, the expression of HIF-1α and HIF-2α was markedly lower in gliosarcoma cells (3% and 1.7%, respectively) and SW48 colorectal carcinoma cells (8.1–1.9% for HIF-1α and 9.1–4.4% for HIF-2α), while increased levels were observed in astrocytoma, glioblastoma, and ARPE-19 cell lines. This evidence concerns the gene EPAS1 and hemangioblastoma.