VHL and central nervous system neoplasm: The etiopathogenesis of VHL-associated hemangioblastomas is driven by mutations in the VHL gene, which accounts for the unique microenvironment of these CNS tumors, characterized by a strong influence of hypoxia signaling pathways [17,18,19], as these mutations result in the dysregulation of hypoxia-inducible factors (HIFs) [20,21,22,23,24,25].