Neuroimaging studies in patients have revealed that CNS hemangioblastomas (CNS-HBs) exhibit distinct growth patterns, saltatory (72%), linear (6%), or exponential (22%) [9], with increased growth being associated with male sex, symptomatic tumors, hemangioblastoma-associated cysts, and germline VHL intragenic deletions [10]. This evidence concerns the gene VHL and hemangioblastoma.