CYP1B1 and isolated aniridia: Pathogenic variants in CYP1B1 have been known to cause not only PCG but also anterior segment dysgenesis 6 (e.g., Peters anomaly, Axenfeld–Rieger anomaly, ectropion uveae with partial aniridia and complete aniridia) [44,45,46,47,48] and juvenile open-angle glaucoma (JOAG), and can even significantly increase the risk for primary open-angle glaucoma (POAG) [17,38,49,50].