MAMDC2 and colorectal carcinoma: Moreover, we performed GSEA, which demonstrated that MAMDC2 was significantly enriched in the gene sets associated with EMT (NES = 1.491, P.adj < 0.001, FDR < 0.001) and myogenesis (NES = 1.379, P.adj < 0.001, FDR < 0.001), suggesting a potential association between MAMDC2 and CRC metastasis-related pathways (Figure 5C,D).