We classified 480 tumor samples from the TCGA-COAD dataset into these subtypes, resulting in CMS1 (n = 84, 17.5%), CMS2 (n = 145, 30.2%), CMS3 (n = 71, 14.8%), CMS4 (n = 138, 28.8%), and mixed subtypes (n = 42, 8.75%), and focused on the differential expression of 18 MAM family genes in these CMS subtypes. This evidence concerns the gene SGCG and neoplasm.