It has been shown that miRNAs influence the fibrotic process in SSc in several ways—by targeting signaling pathways, including the transforming growth factor (TGF)/Smad3 canonical pathway, along with the connective tissue growth factor (CTGF) and NOTCH signaling pathways; contributing to the regulation of the epithelial-to-mesenchymal transition (EMT); promoting myofibroblast proliferation; and enhancing resistance to apoptosis [10,25,26]. The gene discussed is CCN2; the disease is systemic sclerosis.