Epigenetic regulation of SSc endothelial cell responses to VEGF has been found by Wang et al. The authors found that the downregulation of miR-126 and its gene (EGFL7) in SSc endothelial cells and skin is associated with alterations to VEGF by suppressing its negative regulators—sprouty-related protein-1 (SPRED1) and phosphoinositide-3 kinase regulatory subunit 2 (PIK3R2) [83]. The gene discussed is SPRED1; the disease is systemic sclerosis.