In contrast, overweight, obesity, increased lipogenesis, and hepatic steatosis exacerbate SHBG synthesis inhibitory factors (e.g., chicken ovalbumin upstream promoter transcription factor (COUP-TF) or peroxisome proliferator-activated receptor gamma (PPARγ)) [24]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.