Conversely, higher levels of CD3 on naive CD8+ T cell, CD3 on CD28+ CD45RA- CD8+ T cell, FSC-A on CD8+ T cell, TCRγδ T cell %lymphocyte, CD19 on memory B cell, and TCRγδ T cell %T cell were significantly linked to a decreased risk of ME/CFS. The gene discussed is CD28; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.