However, no specific mechanisms were highlighted between obesity and PCa progression [48], despite hyperinsulinemia, higher levels of growth factors, inflammation and its related cytokines and chemokines, alterations in steroid hormones and adiponectin levels and other factors (dysfunctions in microbiome, angiogenesis) have been mentioned [70,71]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.