We first examined the ability of circDNA and circRNA to rescue ANGPTL1 and SOCS3 mRNA expression by sequestering corresponding upstream miRNA clusters (miR-9-5p, miR-182-5p, miR-19a-3p) in the FAK pathway, as identified by KEGG analysis in HCC cells. Here, ANGPTL1 is linked to hepatocellular carcinoma.