The primary objective of this study was to evaluate the associations between baseline levels of CKD-MBD markers (including iPTH, calcium, phosphorus, 25(OH)D, and soluble Klotho) and inflammatory biomarkers (IL-6, CRP, TGF-β, VEGF) with overall mortality in hemodialysis patients. Here, KL is linked to Marchiafava-Bignami disease.