A study evaluating the effect of the prior consumption of HFD for 3, 4, and 5 weeks (21, 28, and 35 days) and the injection of STZ (25 mg/kg, i.p., single dose) after one week revealed that Wistar rats of both sexes (200–300 g) demonstrated an increase in fasting glycemia and dyslipidemia, with no changes in body weight or serum insulin levels in the group fed an HFD for 3 weeks. This evidence concerns the gene INS and metabolic syndrome.