A diverse array of angiogenic mediators play pivotal roles in the pathogenesis of Inflammatory Bowel Disease (IBD), including Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Fibroblast Growth Factors (FGFs), angiopoietins, Matrix Metalloproteinases (MMPs), and several other factors. This evidence concerns the gene VEGFA and inflammatory bowel disease.