Studies have shown that in IBD patients, MT1-MMP promotes the binding of its C-terminal fragment to αvβ3 integrin by cleaving matrix protein TSP1, thereby inducing nitric oxide (NO) production and vasodilation, initiating the IA process, degrading the extracellular matrix to promote neovascularization, and further enhancing local inflammation [61]. The gene discussed is MMP14; the disease is inflammatory bowel disease.