Moreover, it has been demonstrated that NRF2 induces the expression of TRX1 in non-small cell lung cancer [96] and NADPH quinone oxidoreductase 1 (NQO1) in human colorectal and breast cancer cell lines [97], which have been shown to increase HIF-1α levels by prolonging its lifespan (stabilization). This evidence concerns the gene NQO1 and breast carcinoma.