Nuechterlein N et al. demonstrated that elevated HOXD12 expression and genomic hypermethylation are associated with older patient age, shorter survival, and older aggressive oligodendroglioma subtypes, which are independently prognostic of NOTCH1 and PIK3CA mutations, loss of 15q, MYC activation, and standard histopathological features [54]. The gene discussed is PIK3CA; the disease is oligodendroglioma.