IRF3 and viral infectious disease: They demonstrated that the oncometabolite D-2-hydroxyglutarate (D2HG), produced by mutant IDH1, suppresses the expression of Interferon Regulator Factors 3 and 7 (IRF3/7) through a DNA methyltransferase 1 (DNMT1)-dependent mechanism [78]; however, IRF3/7 is a critical transcription factor that may regulate the induction of type I interferon genes and innate immune responses following viral infection [78].