GCG and obesity due to melanocortin 4 receptor deficiency: As obesity is an inflammatory state, it is conceivable that weight loss would have an immune-modulatory effect on these IMIDs, however, there is also evidence to suggest that immune modulation occurs even before weight loss transpires in those treated with GLP-1RAs [46,58,59] and bariatric surgery [60], where there is a surge in native GLP-1 levels.