In multivariable-adjusted Cox models, higher levels of KYN were associated with an increased risk of cardiovascular disease (HR 1.33; 95% CI: 1.19–1.49), while elevated KTR also conferred higher risk (HR 1.24; 95% CI: 1.14–1.35), independent of traditional risk factors and CRP levels [25]. Here, CRP is linked to cardiovascular disorder.