NR3C2 and Abnormal renal physiology: Patients in T3 were significantly more likely to be prescribed loop diuretics (30.5%) and mineralocorticoid receptor antagonists (18.9%) compared to those in T1 (9.7% and 6.1%, respectively; both p < 0.001 and p = 0.001), likely reflecting a higher burden of heart or renal dysfunction.