The Kv8.2 variant with H205 and R252 substituted for R205 and Q252 is associated with an epilepsy phenotype, but both variants form heteromeric assemblies with Kv2.1 and exhibit only minor differences in the heteromeric channel currents, which does not explain the severity of the phenotype [49,50]. The gene discussed is KCNV2; the disease is epilepsy.