This Mendelian randomization analysis identified that CFHR5, CHRDL2, LRP11, and SPARCL1 were associated with an increased risk of CRC, whereas ENPP5, HYAL1, NCR1, and POSTN were linked to a decreased risk of CRC (Figure 3 and Figure 4). The gene discussed is HYAL1; the disease is colorectal carcinoma.